AB0152 PROSPECTIVE ANALYSIS OF OBSTRUCTIVE SLEEP APNEA IN NEWLY DIAGNOSED PATIENTS WITH RHEUMATOID ARTHRITIS, PSORIATIC ARTHRITIS AND PERIPHERAL SPONDYLOARTHRITIS – A SCREENING STUDY

Background: An increased prevalence of obstructive sleep apnea (OSA) in patients with rheumatoid arthritis (RA), psoriatic (PsA) and partially peripheral spondylarthritis (pSpA) has been noted described for nearly two decades. Until now, there is no study yet on the occurrence OSA these entities at point first diagnosis. Identifying treating could prove pivotal improving cardiovascular risk quality life. Furthermore, clinicians require insights into whom to screen. Objectives: To assess early RA, PsA pSpA strategies targeted screening. Methods: We performed a prospective diagnosis or pSpA, who were screened day sleepiness (assessed by Epworth scale) tested disorders out-of-center polygraphy (employing Embletta® MPR-PG devices) University Hospital Bonn, Germany. Findings assessed three physicians, always including an attending physician responsible certified laboratory. Results: A total 22 RA (52.38%), 15 (35.7%), 5 (11.9%) included. Day screening was unremarkable (ESS <10) 29 (69%) suspicious disorder (ESS≥10) 13 (31%). Subsequent studies five severe (AHI >15/h), eight (19.1%) low-to-moderate 5-15/h) (69.1%) <5). Of results, none symptomatic as ESS ≥10, resulting guideline-confirming referrals inpatient polysomnography/ventilation therapy. In comparison PsA/pSpA group, had significant relationship results (p≈0.23), nor AHI ≥5/h (p≈0.14). The male cohort yielded more pathological studies, but result not (16% vs. ~5.9%, p≈0.32). Higher scores (≥10) predictive findings which referral (p≈0.37). Increased BMI (≥25 kg/m 2 ) associated > 5/h (p≈0.63). Conclusion: From screening, number needed screen 8.4 (6.25 male, 17 female group), speaks favor overall cost-efficient newly diagnosed diseases. different design, comparing established cohorts necessary role disease duration possible development OSA. References: [1]Chung W-S, Lin C-L. Sleep arthritis. Breath [Internet]. 2018 Dec 10 [cited 11];22(4):1083–91. Available from: http://www.ncbi.nlm.nih.gov/pubmed/29428977 . [2]Vakil M, Park S, Broder A. complex associations between auto-immune disorders: review. Med Hypotheses 2018;110:138–43. https://doi.org/10.1016/j.mehy.2017.12.004 [3]Wali Mustafa Manzar D, Bawazir Y, Attar Fathaldin O, et al. Prevalence J Clin Med. 2020. Table 1. Patient characteristics Total (n=42 (n=22 (n=15 (n=5 Age Median (IQR) 49 (36-61) 58 (39-64) 43 (30-55) 39 (39-46) Sex Male 25 (59.5%) (68.2%) 6 (40%) 4 (80%) Female (40.5%) 7 (31.8%) 9 (60%) 1 (20%) Obesity (<25/≥25 Normal weight/ Underweight 19 (45.2%) (45.5%) (46.6%) Overweight/ 23 (54.8%) 12 (55.5%) 8 (53.3%) 3 Score <10 (77.3%) ≥10 (31%) (22.7%) (46.7%) <5/h (59.1%) 5-15/h (27.3%) (6.7%) >15/h (13.6%) (13.3%) 0 (0%) – arthritis, spondyloarthritis, IQR interquartile range, body mass index, Sleepiness Scale, Apnea/Hypopnea Index Disclosure Interests: None declared